Endocrine Abstracts

Background: Congenital hyperinsulinism (CHI) is a disorder of unregulated insulin secretion causing persistent hypoglycaemia. In around 50% of the patients with CHI, the underlying molecular genetic etiology is unknown. Ca2+/calmodulin-dependent protein kinase 2 (CaMKK2) belongs to the Serine/Threonine protein kinase family. Alternative splicing results in multiple transcripts encoding distinct isoforms. We report, for the first time, CaMKK2 mutati...

Background: Hypertension (HT) is common in adults with Turner Syndrome (TS) but less is known about HT in children with TS.Aim: To determine the frequency of HT in girls with TS in West of Scotland and to assess its association with clinical characteristics. Patients and methods Retrospective cross-sectional analysis of 126 girls with TS in the West of Scotland, with at least 2 clinic blood pressure (BP) measurements in the preceding 12 months. HT was de...

Background: The prevalence rate of Diabetes within Manchester is higher than the national average of England. Association of British Clinical Diabetologists (ABCD) guidance highlights an increased risk of typical and atypical presentations of diabetic emergencies in patients with Diabetes and COVID-19. In the absence of early recognition and treatment, this could lead to adverse outcomes and poor prognosis, thus leading to increased mortality rates.Aims:...

Introduction: The cystic nodule is an unusual presentation of papillary thyroid carcinoma (PTC), seen in less than 10% of cases. Ultrasound discovery of a thyroid cyst represents less than 5% risk of malignancy. We report the case of a patient followed for papillary thyroid carcinoma in its cystic form.Observation: A 42-year-old patient with no specific history. The patient underwent a right isthmolobectomy for a thyroid nodule. Anatomopathological exami...

Hyperthyroidism is a clinical situation characterized by an excess of thyroid hormones in the circulation, the most common etiology of which is Graves’ disease. Its treatment is based on ATS, iodine 131 and surgery. The iratherapy, object of our study, is a treatment of current practice. It is a simple and radical treatment whose goal is to switch to euthyroidism or hypothyroidism. In case of failure or recurrence, a 2nd or even a 3rd cure is prescribed. We conducted a re...

Background: Animal-derived protein consumption has been rising globally, driven by socioeconomic factors and shifts in dietary patterns to improve performance and support weight loss. In recent years an increasing trend has been observed for plant-based proteins due to sustainability concerns. Previous studies indicate that the metabolic effects of proteins may vary according to their origin. Thus, the aim of this single-blind, crossover study was to assess the acute effects o...

Introduction: Sarcoidosis is a multisystem granulomatous disorder. It commonly causes mild hypercalcemia in up to 10–20% of the cases and renal involvement can be a feature. Presentation with severe symptomatic hypercalcaemia (>3.5 mmol/l) and acute kidney injury is rare. We present an interesting case.Case: A 58 year old female was referred to the emergency department by her general practitioner with a one month history of polyuria, generalised wea...

A 46 year old female presented with 12 months history of secondary amenorrhoea. Prolactin was 4746 mIU/l without macroprolactin complexes, LH & FSH were low, oestradiol was undetectable. She had normal visual fields. No other clinical or biochemical features of pituitary dysfunction. She had no regular medication. Pituitary MRI was normal. She was started on cabergoline 250 mcg twice weekly which was subsequently increased to 500 mcg twice weekly. Repeat serum prolactin 5 ...

Introduction: Blood groups and the Rh factor are involved in several pathologies. Some studies have also identified them as risk factors for diabetes. The objective of this work is to evaluate the possible association between ABO blood groups, rhesus (Positive, Negative) and the risk of diabetes.Patients and methods: This is a case-control study involving 257 diabetic patients followed in the hygiene department and 266 controls followed at Sidi Othmane H...

Introduction: Obesity is a risk factor for cardiovascular disease and diabetes. The objective of this work is to study the prevalence of obesity among a consultant population at the Hygiene Service of the Sidi-Othman District (ASO) in Casablanca.Patients and methods: This is a case-control study of subjects consulting the Sidi Othmane hygiene service. Socio demographic, anthropometric data (weight, height, waist circumference, hip circumference, body mas...